Amphiphilic Dendritic Copolymers of Tert-butyl-glycidylether and Glycidol as a Nanocontainer for an Anticancer Ruthenium Complex
PBN-AR
Instytucja
Centrum Materiałów Polimerowych i Węglowych Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
ISSN
0887-624X
EISSN
Wydawca
WILEY-BLACKWELL
DOI
URL
Rok publikacji
2014
Numer zeszytu
24
Strony od-do
3488-3497
Numer tomu
52
Identyfikator DOI
Liczba arkuszy
Autorzy
Pozostali autorzy
+ 3
Słowa kluczowe
en
metal-polymer complex;
polyethers;
star polymers;
TEM
en
DRUG-DELIVERY;
HYPERBRANCHED POLYGLYCEROLS;
ARBORESCENT POLYOXYETHYLENE;
CATIONIC-POLYMERIZATION;
POLYMERS;
DENDRIMERS;
CYTOTOXICITY;
POLYGLYCIDOL;
NANOCARRIERS;
MECHANISM
Streszczenia
Język
en
Treść
Dendritic copolymers comprising a hydrophobic core and hydrophilic shell with nearly equal numbers of hydroxyl groups in the shell and different densities in the core were prepared by a multi-step process based on anionic ring-opening polymerization. The diversity in the core density was obtained by using copolymer stars with poly(tert-butyl-glycidylether)-block-polyglycidol arms with nearly equal length of hydrophobic blocks and numbers of hydroxyl groups of polyglycidol but different numbers of arms as macroinitiators. The ability of the dendritic copolymers to serve as a nanocontainer for a ruthenium complex Ru(NH3)(3)Cl-3 with anticancer properties was studied. The possibility of improving the water solubility of this poorly soluble drug by loading it onto dendritic copolymers was investigated. The hydroxyl groups of the dendritic copolymers were used for complexation of the ruthenium compound to the shell. The loading efficiency was analyzed by UV-vis spectroscopy. The dendritic nanoparticles in their hydrated state were visualized using cryo-TEM. (c) 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 3488-3497
Cechy publikacji
oryginalny artykuł naukowy
Inne
System-identifier
PX-560cf3a28106bf9644bcb415
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