Placental vascular endothelial growth factor expression in pregnancies complicated by type I diabetes
PBN-AR
Instytucja
Instytut Włókien Naturalnych i Roślin Zielarskich
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Journal of Physiology and Pharmacology
ISSN
0867-5910
EISSN
1899-1505
Wydawca
POLISH PHYSIOLOGICAL SOCIETY
DOI
Rok publikacji
2014
Numer zeszytu
4
Strony od-do
577-583
Numer tomu
65
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
angielski
diabetes
pregnancy
vascular endothelial growth factor
single nucleotide polymorphisms
placenta
macrosomia
Streszczenia
Język
angielski
Treść
Type 1 diabetes mellitus (T1DM) is still associated with increased risk of severe maternal and foetal complications but their pathomechanism remains unclear. Objectives: we investigated the possible role of placental vascular endothelial growth factor (VEGF) and VEGF single nucleotide polymorphisms (SNP) in foetal development in T1DM pregnancies. Sixty seven pregnant women with T1DM and singleton pregnancy were enrolled into the study. Results demonstrated higher expression of placental VEGF in women who delivered neonates with birth weight (NBW)>4000g. No such correlation was found in the overall T1DM group and in women who delivered appropriate for gestational age (AGA) and small for gestational age (SGA) newborns. We also demonstrated a significant correlation between 3rd trimester mean blood glucose, HbA1C and placental VEGF. No such correlation was found for the 1st and 2nd trimesters. Top placental VEGF expression and placental mass were found in women who delivered large for gestational age (LGA) newborns. We also found a statistically significant difference in homozygous and heterozygous frequency variants of VEGF SNPs in study groups. We conclude that the increased placental VEGF together with impaired metabolic control may have a role in stimulating foetal overgrowth in T1DM pregnancy.
Cechy publikacji
Medycyna
Nauki farmaceutyczne
Medicine
Pharmacy
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:641625