DRD2 C313T and DRD4 48-bp VNTR polymorphisms and physical activity of healthy men in Lower Silesia, Poland (HALS study)
PBN-AR
Instytucja
Wydział Sportu (Akademia Wychowania Fizycznego we Wrocławiu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
ANNALS OF HUMAN BIOLOGY
ISSN
0301-4460
EISSN
1464-5033
Wydawca
INFORMA HEALTHCARE
DOI
URL
Rok publikacji
2013
Numer zeszytu
2
Strony od-do
186-190
Numer tomu
40
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
dopamine D2 receptor
dopamine D4 receptor
genetic polymorphism
lifestyle
motor activity
Streszczenia
Język
en
Treść
Background: Both animal and human studies have proved that the dopaminergic system of the brain controls many aspects of behavior, e.g. motivation, addiction, motor movement, locomotion. It has been hypothesized that dopamine signalling may regulate spontaneous physical activity as well. Aim: Literature data suggests that an intact function of dopamine receptors (DRD2–DRD4) inhibits physical activity. This study searched for associations between a propensity to be active (or sedentary) and genetic variants of DRD2 and DRD4. Subjects and methods: Invitations to participate in the study were sent to 900 randomly selected, adult men living in Lower Silesia, Poland. Genotyping of DRD2 C313T and DRD4 48-bp VNTR polymorphisms of enrolled subjects (371 (DRD2 C313T) and 397 (DRD4 48-bp VNTR)) was performed. Level of physical activity was evaluated using the International Physical Activity Questionnaire (IPAQ). Results: No associations were found between level of physical activity (low, moderate, high) and the two polymorphisms: DRD2 C313T (p = 0.49) and DRD4 48-bp VNTR (p = 0.31). Studied subjects did not differ as to the number of hours spent sitting either. Conclusion: The results exclude the presence of significant relationships between polymorphic variants of the dopamine receptors genes and the level of physical activity in men.
Cechy publikacji
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:556423
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