Association of early protein intake and pre-peritoneal fat at five years of age: follow-up of a randomized clinical trial.
PBN-AR
Instytucja
Instytut "Pomnik - Centrum Zdrowia Dziecka"
Informacje podstawowe
Główny język publikacji
en
Czasopismo
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
ISSN
0939-4753
EISSN
1590-3729
Wydawca
Elsevier
Rok publikacji
2016
Numer zeszytu
9
Strony od-do
824-832
Numer tomu
26
Identyfikator DOI
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Autorzy
Pozostali autorzy
+ 10
Słowa kluczowe
en
infant formula
protein
dietary proteins
intra-abdominal fat
subcutaneous fat
child
Streszczenia
Język
en
Treść
BACKGROUND AND AIMS: The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial. METHODS AND RESULTS: Healthy term formula-fed infants in five European countries were randomized either to higher (n = 550) or lower (n = 540) protein formulas in the first year of life. Infants who were exclusively breastfed for at least three months (n = 588) were enrolled as an observational (non randomized) group. At age 5 years, subcutaneous fat (SC) and pre-peritoneal fat (PP) were measured by ultrasound in a subgroup of 275 children. The PP fat layer was thicker in the higher compared to the lower protein group (adjusted estimated difference: 0.058 cm, 95%CI 0.002; 0.115; p = 0.043), while SC fat was not different. Girls showed a thicker SC fat layer than boys. CONCLUSIONS: Higher protein intake in formula-fed infants appears to enhance pre-peritoneal fat tissue accumulation at the age of 5 years, but not of subcutaneous fat, which may trigger adverse metabolic and health consequences.
Cechy publikacji
original-article
Inne
System-identifier
0000015350
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