Dietary 2-oxoglutarate prevents bone loss caused by neonatal treatment with maximal dexamethasone dose
PBN-AR
Instytucja
Centrum Innowacji STB sp. z o.o. sp. k.
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Experimental Biology and Medicine (30pkt w roku publikacji)
ISSN
1535-3702
EISSN
1535-3699
Wydawca
SOC EXPERIMENTAL BIOLOGY MEDICINE
DOI
URL
Rok publikacji
2017
Numer zeszytu
7
Strony od-do
671-682
Numer tomu
242
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 5)
Pozostali autorzy
+ 4
Słowa kluczowe
en
Glutamine derivative
glucocorticoids
newborn
osteoporosis
supplementation
Streszczenia
Język
en
Treść
Synthetic glucocorticoids (GCs) are widely used in the variety of dosages for treatment of premature infants with chronic lung disease, respiratory distress syndrome, allergies, asthma, and other inflammatory and autoimmune conditions. Yet, adverse effects such as glucocorticoid-induced osteoporosis and growth retardation are recognized. Conversely, 2-oxoglutarate (2-Ox), a precursor of glutamine, glutamate, and collagen amino acids, exerts protective effects on bone development. Our aim was to elucidate the effect of dietary administered 2-Ox on bone loss caused by neonatal treatment with clinically relevant maximal therapeutic dexamethasone (Dex) dose. Long bones of neonatal emale piglets receiving Dex, Dexþ2-Ox, or untreated were examined through measure-ments of mechanical properties, density, mineralization, geometry, histomorphometry, and histology. Selected hormones, bone turnover, and growth markers were also analyzed. Neonatal administration of clinically relevant maximal dose of Dex alone led to over 30% decrease in bone mass and the ultimate strength (P < 0.001 for all). The length (13 and 7% for femur and humerus, respectively) and other geometrical parameters (13–45%) decreased compared to the control (P < 0.001 for all). Dex impaired bone growth and caused hormonal imbalance. Dietary 2-Ox prevented Dex influence and vast majority of assessed bone parameters were restored almost to the control level. Piglets receiving 2-Ox had heavier, denser, and stronger bones; higher levels of growth hormone and osteocalcin concentration; and preserved microarchitecture of trabecular bone compared to the Dex group. 2-Ox administered postnatally had a potential to maintain bone structure of animals simultaneously treated with maximal therapeutic doses of Dex, which, in our opinion, may open up a new opportunity in developing combined treatment for children treated with GCs.
Cechy publikacji
discipline:Biochemia – dziedzina nauk biologicznych
discipline:Biologia
discipline:Biologia medyczna
discipline:Biotechnologia – dziedzina nauk biologicznych
discipline:Technologia żywności i żywienia
discipline:Zootechnika
discipline:Biochemistry – field of biological sciences
discipline:Biology
discipline:Medical biology
discipline:Biotechnology – field of biological sciences
discipline:Food and nutrition sciences
discipline:Zootechnics
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:804400
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