Combinatorial identification of DNA methylation patterns over age in the human brain
PBN-AR
Instytucja
Instytut Podstaw Informatyki Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
BMC BIOINFORMATICS
ISSN
1471-2105
EISSN
Wydawca
BIOMED CENTRAL LTD
DOI
URL
Rok publikacji
2016
Numer zeszytu
17:393
Strony od-do
1-10
Numer tomu
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 5)
Pozostali autorzy
+ 4
Słowa kluczowe
angielski
DNA methylation
Aging
Rule-based classification
Feature selection
Streszczenia
Język
angielski
Treść
Background DNA methylation plays a key role in developmental processes, which is reflected in changing methylation patterns at specific CpG sites over the lifetime of an individual. The underlying mechanisms are complex and possibly affect multiple genes or entire pathways. Results We applied a multivariate approach to identify combinations of CpG sites that undergo modifications when transitioning between developmental stages. Monte Carlo feature selection produced a list of ranked and statistically significant CpG sites, while rule-based models allowed for identifying particular methylation changes in these sites. Our rule-based classifier reports combinations of CpG sites, together with changes in their methylation status in the form of easy-to-read IF-THEN rules, which allows for identification of the genes associated with the underlying sites. Conclusion We utilized machine learning and statistical methods to discretize decision class (age) values to get a general pattern of methylation changes over the lifespan. The CpG sites present in the significant rules were annotated to genes involved in brain formation, general development, as well as genes linked to cancer and Alzheimer’s disease.
Inne
System-identifier
PX-58e79a9dd5de5fe179346354
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