Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium
PBN-AR
Instytucja
Instytut Hematologii i Transfuzjologii
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (40pkt w roku publikacji)
ISSN
1055-9965
EISSN
Wydawca
AMER ASSOC CANCER RESEARCH
DOI
URL
Rok publikacji
2017
Numer zeszytu
8
Strony od-do
1349-1351
Numer tomu
26
Identyfikator DOI
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Autorzy
(liczba autorów: 32)
Pozostali autorzy
+ 31
Streszczenia
Język
angielski
Treść
Background: Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms for which very little is known about either environmental or genetic risk factors. Only a handful of association studies have been performed so far, suggesting a small number of risk loci. Methods: To replicate the best findings, we have selected 16 SNPs suggested in previous studies to be relevant in PNET etiogenesis. We genotyped the selected SNPs (rs16944, rs1052536, rs1059293, rs1136410, rs1143634, rs2069762, rs2236302, rs2387632, rs3212961, rs3734299, rs3803258, rs4962081, rs7234941, rs7243091, rs12957119, and rs1800629) in 344 PNET sporadic cases and 2,721 controls in the context of the PANcreatic Disease ReseArch (PANDoRA) consortium. Results: After correction for multiple testing, we did not observe any statistically significant association between the SNPs and PNET risk. We also used three online bioinformatic tools (HaploReg, RegulomeDB, and GTEx) to predict a possible functional role of the SNPs, but we did not observe any clear indication. Conclusions: None of the selected SNPs were convincingly associated with PNET risk in the PANDoRA consortium. Impact: We can exclude a major role of the selected polymorphisms in PNET etiology, and this highlights the need for replication of epidemiologic findings in independent populations, especially in rare diseases such as PNETs.
Cechy publikacji
inny o charakterze cytowalnym
Other citable
short communication
doniesienie o wynikach badań
Inne
System-identifier
PX-59918793d5de07c1c81a2847
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