Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
CURRENT DRUG METABOLISM (40pkt w roku publikacji)
ISSN
1389-2002
EISSN
Wydawca
BENTHAM SCIENCE PUBL LTD
DOI
URL
Rok publikacji
2017
Numer zeszytu
4
Strony od-do
306-345
Numer tomu
18
Liczba arkuszy
3.00
Słowa kluczowe
en
Antidiuretic hormone
biomarkers
cardiovascular diseases
neuropeptides
psychiatric disorders
vaptans
Streszczenia
Język
en
Treść
Vasopressin (AVP) and its receptors play a pivotal role in maintaining body homeostasis under physiological and pathophysiological conditions. As a consequence, the vasopressin system has emerged as an important target for both diagnostic and therapeutic applications in a number of medical conditions. Stoichiometric generation of AVP with copeptin, which is relatively accessible in the blood for measurements, makes copeptin a valuable surrogate of AVP. In this review, we present the regulation of release of AVP and activation of V1a, V1b, and V2 vasopressin receptors under physiological and pathological conditions. We make a survey of the role of AVP in: the regulation of the cardiovascular system; body fluid osmolality; natraemia; endocrine regulation; food intake; metabolism; circadian rhythmicity, immunological processes; and in the formation of learning, memory, cognition, and emotional and social behaviours. We also discuss the significance of the inappropriate functioning of the vasopressin system for: the development of cardiovascular diseases; disturbances of the water-electrolyte balance; energy metabolism; inflammatory processes; pain; neurogenic stress; memory disorders; depression; anxiety; autism; and schizophrenia. The structure and biological properties of peptide and non-peptide agonists and antagonists of V1a, V1b and V2 vasopressin receptors are presented and the potential use of copeptin and the current and likely indications for AVP agonists and antagonists in the diagnosis and therapeutics of multiple pathological conditions is discussed.
Cechy publikacji
discipline:Biologia medyczna
discipline:Nauki farmaceutyczne
discipline:Medical biology
discipline:Pharmacy
Review article
Review article is a summarization of the current state of the research on a particular subject.
Artykuł przeglądowy
Artykuł przeglądowy stanowi podsumowanie aktualnego stanu badań w danym obszarze tematycznym.
Inne
System-identifier
PBN-R:817978
CrossrefMetadata from Crossref logo
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