Antidepressant activity of zinc: Further evidence for the involvement of the serotonergic system
PBN-AR
Instytucja
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Pharmacological Reports (25pkt w roku publikacji)
ISSN
1734-1140
EISSN
Wydawca
Elsevier Sp. z o.o.
DOI
Rok publikacji
2017
Numer zeszytu
3
Strony od-do
456-461
Numer tomu
69
Identyfikator DOI
Liczba arkuszy
Autorzy
Pozostali autorzy
+ 1
Streszczenia
Język
angielski
Treść
Background The present study sought to further evaluate the role of the serotonergic system especially the postsynaptic 5-HT1A receptors (5-HT1AR) in the mechanism of antidepressant action of zinc. Methods Messenger RNA (mRNA), protein level, and 5-HT1AR density as well as the rate of monoamine (dopamine, DA, and serotonin) metabolism in the prefrontal cortex (PFC) and hippocampus (Hp) of rats subjected to acute and chronic (21 days) zinc (5 mg Zn/kg) treatment were measured. Results Acute or chronic zinc treatment did not induce any changes in 5-HT1AR mRNA levels in the PFC or Hp of rats. However, chronic zinc treatment induced increases in both 5-HT1AR protein levels and density of 5-HT1A receptor binding sites in the Hp of rats. Chronic zinc treatment also increased tissue levels of serotonin metabolite and turnover in the rat Hp. On the other hand, DA, DOPAC, HVA tissue levels increased while DOPAC/DA and 3MT/DA decreased in the PFC of rats after chronic zinc treatment. Acute treatment induced increases only in tissue levels of DOPAC, and DOPAC/DA. Conclusions Our results confirm that the antidepressant effects of zinc are mediated in concert with the modulation of the serotonergic system including postsynaptic 5-HT1ARs and allude to a possible involvement of dopaminergic neurotransmission in this action.
Inne
System-identifier
PX-59831c18d5deb0738e572d0e
CrossrefMetadata from Crossref logo
Cytowania
Liczba prac cytujących tę pracę
Brak danych
Referencje
Liczba prac cytowanych przez tę pracę
Brak danych