Possible protective role of elderberry fruit lyophilizate against selected effects of cadmium and lead intoxication in Wistar rats
PBN-AR
Instytucja
Wydział Rolniczo-Ekonomiczny (Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Environmental Science and Pollution Research
ISSN
0944-1344
EISSN
Wydawca
DOI
URL
Rok publikacji
2016
Numer zeszytu
9
Strony od-do
8837-8848
Numer tomu
23
Identyfikator DOI
Liczba arkuszy
0.55
Autorzy
(liczba autorów: 5)
Pozostali autorzy
+ 4
Słowa kluczowe
en
Antioxidants; Cadmium; Elderberry fruit lyophilizate; Lead; Rats
Streszczenia
Język
en
Treść
The objective of this study was the investigation whether the administration of the elderberry fruit lyophilizate under exposure to cadmium(Cd) and (Pb) lead may protect against some effects of their toxic action in Wistar rats. Rats were fed with diets containing Cd (Cd 0.025 mg/kg b.m.) or Pb (Pb 0.025 mg /kg b.m.) with the addition of the freeze-dried elderberry fruits (BEF) in the amount of 5 %. BEF added to the diet with Cd significantly decreased the activity of AST and ALT compared to the rats fed with the control diet with Cd (C + Cd). Activity of glutathione peroxidase was significantly higher in the blood of rats fed with BEF diet compared with animals fed with BEF + Cd, BEF + Pb, and C + Pb diets. Addition of BEF to the diets with Cd or Pb significantly decreased the uric acid concentration compared to the level of this parameter in the serum of animals fed with control diets containing Cd or Pb. The level of the Cd significantly decreased in the livers of rodents fed with BEF + Cd diet as compared to the concentration of this metal in the livers of rats fed with C + Cd diet. Elderberry fruit lyophilizate did not protect against the increased concentration of Cd or Pb in kidneys and bones of experimental rats; however, it improved the function of livers and kidneys, especially of rats intoxicated with Cd.
Inne
System-identifier
UR79812f894a1a4782a3307113c626cefb
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