Characterisation, \emph{in vitro} release study, and antibacterial activity of montmorillonite-gentamicin complex material
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Materials Science and Engineering. C, Materials for Biological Applications (30pkt w roku publikacji)
ISSN
0928-4931
EISSN
1873-0191
Wydawca
Elsevier Science BV
DOI
Rok publikacji
2017
Numer zeszytu
Strony od-do
471--478
Numer tomu
70
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
0.57
Autorzy
Pozostali autorzy
+ 3
Słowa kluczowe
EN
montmorillonite
X-ray methods
gentamicin
antibacterial activity
controlled drug release
Streszczenia
Język
EN
Treść
The present paper concerns the potential use of montmorillonite as a drug carrier and focusses on the intercalation of the studied clay with gentamicin (an aminoglycoside antibiotic) at various temperatures (20, 50 and 80 °C). The experiments were performed to identify the temperature required for the optimum intercalation of gentamicin into the interlayer of montmorillonite. The structural and microstructural properties of gentamicin and the potential for introducing it between smectite clay layers were investigated by means of X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopic techniques, and SEM with EDS analysis. Additionally, the in vitro drug release behaviour of the montmorillonite-gentamicin complex and its antibacterial activity against Escherichia coli (E. coli) bacteria was investigated. Based on these studies, the impact of temperature on the intercalation of the drug between layers of smectite was evaluated. It was found that an intercalation temperature of 50 °C resulted in the highest shift in the position of principle peak d(001) as measured by XRD, suggesting, that the greatest amount of gentamicin had been introduced into the interlayer space of montmorillonite at this temperature. Subsequently, the montmorillonite-gentamicin complex material obtained at 50 °C revealed the greatest capacity for killing E. coli bacteria during an in vitro test. © 2016 Elsevier B.V.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:101374
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