Various ketogenic diets can differently support brain resistance against experimentally evoked seizures and seizure-induced elemental anomalies of hippocampal formation
PBN-AR
Instytucja
Wydział Fizyki i Informatyki Stosowanej (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Journal of Trace Elements in Medicine and Biology (20pkt w roku publikacji)
ISSN
0946-672X
EISSN
1878-3252
Wydawca
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI
Rok publikacji
2017
Numer zeszytu
Strony od-do
50--58
Numer tomu
42
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
0.64
Autorzy
Pozostali autorzy
+ 4
Słowa kluczowe
EN
synchrotron radiation
topographic and quantitative elemental analysis
X-ray fluorescence microscopy
ketogenic diet
hippocampal formation
pilocarpine model of seizures
epilepsy
Streszczenia
Język
EN
Treść
In this paper the influence of two different ketogenic diets (KDs) on the seizure-evoked elemental anomalies of hippocampal formation was examined. To achieve this purpose normal and pilocarpine treated rats previously fed with one of the two high fat and carbohydrate restricted diets were compared with animals on standard laboratory diet. The ketogenic ratios of the examined KDs were equal to 5:1 (KD1) and 9:1 (KD2). KD1 and standard diet fed animals presented similar patterns of seizure-evoked elemental changes in hippocampal formation. Also the analysis of behavioral data recorded after pilocarpine injection did not show any significant differences in intensity and duration of seizures between KD1 and standard diet fed animals. Higher ketogenic ratio KD2 introduced in the normal hippocampal formation prolonged changes in the accumulation of P, K, Zn and Ca. Despite this, both the intensity and duration of seizures were significantly reduced in rats fed with KD2 which suggests that its saving action on the nerve tissue may protect brain from seizure propagation. Also seizure-evoked elemental anomalies in KD2 animals were different than those observed for rats both on KD1 and standard diets. The comparison of seizure experiencing and normal rats on KD2, did not show any statistically significant differences in elemental composition of CA1 and H hippocampal areas whilst in CA3 area only Zn level changed as a result of seizures. DG was the area mostly affected by seizures in KD2 fed rats but areal densities of all examined elements increased in this hippocampal region. © 2017 Elsevier GmbH
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:105543
CrossrefMetadata from Crossref logo
Cytowania
Liczba prac cytujących tę pracę
Brak danych
Referencje
Liczba prac cytowanych przez tę pracę
Brak danych