A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis
PBN-AR
Instytucja
Wydział Lekarski (Uniwersytet Warmińsko-Mazurski w Olsztynie)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Folia Histochemica et Cytobiologica
ISSN
0239-8508
EISSN
1897-5631
Wydawca
VM Media sp. z o.o. VM Group sp. k. Grupa Via Medica
DOI
Rok publikacji
2014
Numer zeszytu
1
Strony od-do
29-35
Numer tomu
52
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 11)
Pozostali autorzy
+ 10
Słowa kluczowe
en
corrosive esophageal burn; stricture; olmesartan; protection; apoptosis; TUNEL; nucleosomes; p53
Streszczenia
Język
en
Treść
Accidentally ingested corrosive substances can cause functional and structural damage to the esophageal tissue resulting in stricture formation. It has been reported that the administration of olmesartan (OLM) can have anti-inflammatory, antifibrotic and antiapoptotic effects on injured tissue. The aim of our study was to check if OLM could prevent formation of scars in the corrosive esophageal burn model. Fifty-one Wistar Albino rats were divided into six groups: Control, Sham, OLM, Sham + OLM, Burn, and Burn + OLM. Olmesartan (5 mg/kg) was given by gavage once per day for 21 consecutive days after injury. The morphology of the esophagus was assessed after Masson trichrome staining, and apoptosis was evaluated using the terminal deoxynucleotidyl transferased UTP nick end labeling (TUNEL) method. The serum nucleosomes (as an indicator of apoptosis), serum p53 protein, and esophageal tissue p53 protein levels of each group were measured by immunoassays. Muscularis mucosa damage, submucosal collagen deposition, and tunica muscularis injury in the Burn + OLM group decreased significantly compared with the Burn group (p < 0.05). Similarly, the number of apoptotic cells in the Burn + OLM group decreased compared with the Burn group (p < 0.05). Serum levels of nucleosomes and p53 and tissue of p53 protein did not differ between the groups. Exogenously administered OLM can effectively prevent the occurrence of esophageal strictures caused by corrosive esophageal burns.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
EX-56b4a0ce8106eb71826fe7db
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