A study on the in vitro percutaneous absorption of silver nanoparticles in combination with aluminum chloride, methyl paraben or di-n-butyl phthalate
PBN-AR
Instytucja
Sieć Badawcza Łukasiewicz - Instytut Włókiennictwa
Informacje podstawowe
Główny język publikacji
en
Czasopismo
TOXICOLOGY LETTERS (35pkt w roku publikacji)
ISSN
0378-4274
EISSN
Wydawca
ELSEVIER IRELAND LTD
DOI
URL
Rok publikacji
2017
Numer zeszytu
Strony od-do
38-48
Numer tomu
272
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
angielski
Aluminum, Di-n-butyl phthalate, Laser ablation, ICP-MS, Methyl paraben, Percutaneous absorption, Silver nanoparticles
Streszczenia
Język
angielski
Treść
Some reports indicate that the silver released from dermally applied products containing silver nanoparticles (AgNP) (e.g. wound dressings or cosmetics) can penetrate the skin, particularly if damaged. AgNP were also shown to have cytotoxic and genotoxic activity. In the present study percutaneous absorption of AgNP of two different nominal sizes (Ag15 nm or Ag45 nm by STEM) and surface modification, i.e. citrate or PEG stabilized nanoparticles, in combination with cosmetic ingredients, i.e. aluminum chloride (AlCl3), methyl paraben (MPB), or di-n-butyl phthalate (DBPH) was assessed using in vitro model based on dermatomed pig skin. The inductively coupled plasma mass spectrometry (ICP-MS) measurements after 24 h in receptor fluid indicated low, but detectable silver absorption and no statistically significant differences in the penetration between the 4 types of AgNP studied at 47, 470 or 750 μg/ml. Similarly, no significant differences were observed for silver penetration when the AgNP were used in combinations with AlCl3 (500 μM), MPB (1250 μM) or DBPH (35 μM). The measured highest amount of Ag that penetrated was 0.45 ng/cm2 (0.365–0.974 ng/cm2) for PEG stabilized Ag15 nm + MPB.
Cechy publikacji
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:811510