Ellagitannins from strawberry with different degree of polymerization showed different metabolism through gastrointestinal tract of rats
PBN-AR
Instytucja
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Journal of Agricultural and Food Chemistry (45pkt w roku publikacji)
ISSN
0021-8561
EISSN
1520-5118
Wydawca
DOI
URL
Rok publikacji
2017
Numer zeszytu
49
Strony od-do
10738-10748
Numer tomu
65
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
ellagitannins
nasutin
urolithin
rat
agrimoniin
strawberry
Streszczenia
Język
en
Treść
The present paper describes a comparative study of the metabolism of 1) ellagic acid, 2) monomeric ellagitannins – a mixture of α- and β-bis-hexahydroxydiphenoyl-D-glucose, and 3) dimeric ellagitannins – mainly agrimoniin with both glucose residues being esterified with hexahydroxydiphenoyl (HHDP), in rats fed polyphenol-rich diets. Their metabolites were identified and quantified in selected parts of the gastrointestinal tract i.e., the stomach, small intestine, and cecum on the 2nd, 4th, and 7th day of the experiment, as well as in the feces, blood serum, and urine of rats. Significant differences between the metabolites of strawberry ellagitannins and ellagic acid were observed in all parts of the gastrointestinal tract. Urolithin A was the predominant polyphenolic metabolite of rats fed a diet supplemented with ellagic acid. On the other hands, in rats fed low DP ellagitannins, the main metabolite was nasutin followed by urolithin A, while ellagitannins with a higher DP led to nasutin only. KEYWORDS: ellagitannins, nasutin, urolithin, rat, agrimoniin, strawberry
Inne
System-identifier
252-002786
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