Endosomal "sort" of signaling control: The role of ESCRT machinery in regulation of receptor-mediated signaling pathways.
PBN-AR
Instytucja
Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Seminars in Cell and Developmental Biology (40pkt w roku publikacji)
ISSN
1084-9521
EISSN
Wydawca
Elsevier
DOI
Rok publikacji
2018
Numer zeszytu
Strony od-do
11-20
Numer tomu
74
Link do pełnego tekstu
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Liczba arkuszy
Słowa kluczowe
angielski
ESCRT;
Endosomes;
Membrane receptors;
Signal transduction;
Signaling proteins
Streszczenia
Język
angielski
Treść
The endosomal sorting complexes required for transport (ESCRTs) machinery consists of four protein assemblies (ESCRT-0 to -III subcomplexes) which mediate various processes of membrane remodeling in the cell. In the endocytic pathway, ESCRTs sort cargo destined for degradation into intraluminal vesicles (ILVs) of endosomes. Cargos targeted by ESCRTs include various signaling molecules, mainly internalized cell-surface receptors but also some cytosolic proteins. It is therefore expected that aberrant trafficking caused by ESCRT dysfunction affects different signaling pathways. Here we review how perturbation of ESCRT activity alters intracellular transport of membrane receptors, causing their accumulation on endocytic compartments, decreased degradation and/or altered recycling to the plasma membrane. We further describe how perturbed trafficking of receptors impacts the activity of their downstream signaling pathways, with or without changes in transcriptional responses. Finally, we present evidence that ESCRT components can also control activity and intracellular distribution of cytosolic signaling proteins (kinases, other effectors and soluble receptors). The underlying mechanisms involve sequestration of such proteins in ILVs, their sorting for degradation or towards non-lysosomal destinations, and regulating their availability in various cellular compartments. All these ESCRT-mediated processes can modulate final outputs of multiple signaling pathways.
Inne
System-identifier
PX-5a92d5ecd5ded246cd7daa74
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