Morphofunctional Renal Alterations in Progeny of Mice Fed Rhodiola kirilowii Extracts or Epigallocatechin During Pregnancy and Lactation.
PBN-AR
Instytucja
Wojskowy Instytut Higieny i Epidemiologii im. gen. Karola Kaczkowskiego
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Journal of Medicinal Food (25pkt w roku publikacji)
ISSN
1096-620X
EISSN
1557-7600
Wydawca
MARY ANN LIEBERT INC
DOI
URL
Rok publikacji
2017
Numer zeszytu
1
Strony od-do
86-92
Numer tomu
20
Identyfikator DOI
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Autorzy
Pozostali autorzy
+ 5
Słowa kluczowe
angielski
medicinal food; medicinal plants; mice; renal impairments
Streszczenia
Język
angielski
Treść
Treating infections in pregnant patients is potentially dangerous even when herbal medicines are used. Many herbal medicines, among them extracts from plants of Rhodiola genus, have antimicrobial, anti-inflammatory, and immunostimulatory properties owing to their polyphenol content; they may, however, affect fetal development due to their antiangiogenic properties. The aim of this study was to explain whether daily feeding pregnant and lactating mice with 20 mg/kg Rhodiola kirilowii aqueous (RKW) or 50% hydro-alcoholic (RKW-A) extracts, or 0.2 mg/kg epigallocatechin (EGC, antiangiogenic compound of Rhodiola extracts), may lead to abnormalities in morphology and function of the kidneys of adult progeny. Such abnormalities were not observed in the kidneys of 6-week-old offspring, neither in RKW nor in the control group. However, the progeny of RKW-A- or EGC-fed mothers presented morphometric abnormalities in the kidney structure, with a significantly higher number of glomeruli/mm2 and a lower diameter of glomeruli (RKW-A group) or a significantly higher glomeruli diameter (EGC), than in the control and RKW groups. Abnormalities in serum vascular endothelial growth factor, tumor necrosis factor (TNF)-alpha, urea, creatinine, and cystatin C levels were also found. We recommend caution in long-term use of RKW-A extract and EGC-rich foods during pregnancy and lactation.
Inne
System-identifier
PX-5a0d8c88d5de60d919fdca4b
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