Clustering of low usage codons in the translation initiation region of hepatitis C virus
PBN-AR
Instytucja
Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy
Informacje podstawowe
Główny język publikacji
en
Czasopismo
INFECTION GENETICS AND EVOLUTION
ISSN
1567-1348
EISSN
Wydawca
ELSEVIER SCIENCE BV
DOI
URL
Rok publikacji
2013
Numer zeszytu
18
Strony od-do
8-12
Numer tomu
Identyfikator DOI
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Autorzy
(liczba autorów: 10)
Pozostali autorzy
+ 9
Słowa kluczowe
en
Hepatitis C virus
Synonymous codon usage value
Overall codon usage pattern
Translation initiation region
Streszczenia
Język
en
Treść
The adaptation of the overall codon usage pattern of hepatitis C virus (HCV) to that of human is estimated by the synonymous codon usage value (RSCU). The synonymous codon usage biases for the translation initiation region (TIR) of this virus are also analyzed by calculation of usage fluctuation of each synonymous codon along the TIR (the first 30 codon sites of the whole coding sequence of HCV). As for the overall codon usage pattern of HCV, this virus has a significant tendency to delete the codons with CpG or TpA dinucleotides. Turning to the adaptation of the overall codon usage of HCV to that of human, over half part of codons has a similar usage pattern between this virus and human, suggesting that the host cellular environment of the overall codon usage pattern influences the formation of codon usage for HCV. In addition, there is no obvious phenomenon that the codons with relatively low energy tend to be highly selected in the TIR of HCV, suggesting that the synonymous codon usage patterns for the TIR of HCV might be not affected by the secondary structure of nucleotide sequence, however, the formation of synonymous codons usage in the TIR of HCV is influenced by the overall codon usage patterns of human to some degree.
Cechy publikacji
short communication
Inne
System-identifier
PX-5a098660d5debff17a7844da
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