Bufadienolides of Kalanchoe species: an overview of chemical structure, biological activity and prospects for pharmacological use
PBN-AR
Instytucja
Instytut Uprawy Nawożenia i Gleboznawstwa - Państwowy Instytut Badawczy
Informacje podstawowe
Główny język publikacji
en
Czasopismo
PHYTOCHEMISTRY REVIEWS (40pkt w roku publikacji)
ISSN
1568-7767
EISSN
1572-980X
Wydawca
SPRINGER
DOI
URL
Rok publikacji
2017
Numer zeszytu
16
Strony od-do
1155–1171
Numer tomu
6
Identyfikator DOI
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Autorzy
Pozostali autorzy
+ 1
Słowa kluczowe
en
Bufadienolide
Kalanchoe
Cytotoxicity
Cancer therapy
Ethnomedicine
Streszczenia
Język
en
Treść
Toad venom is regarded as the main source of bufadienolides; however, synthesis of these substances takes also place in a variety of other animal and plant organisms, including ethnomedicinal plants of the Kalanchoe genus. Chemically, bufadienolides are a group of polyhydroxy C-24 steroids and their glycosides, containing a six-membered lactone (apyrone) ring at the C-17b position. From the pharmacological point of view, bufadienolides might be a promising group of steroid hormones with cardioactive properties and anticancer activity. Most of the literature concerns bufadienolides of animal origin; however, the medicinal use of these compounds remains limited by their narrow therapeutic index and the risk of development of cardiotoxic effects. On the other hand, plants such as Kalanchoe are also a source of bufadienolides. Kalanchoe pinnata (life plant, air plant, cathedral bells), Kalanchoe daigremontiana (mother of thousands) and other Kalanchoe species are valuable herbs in traditional medicine of Asia and Africa. The present review focuses on the available data on chemical structures of 31 compounds, biological properties and prospects for therapeutic use of bufadienolides from Kalanchoe species. Furthermore, it presents some new investigational trends in research on curative uses of these substances.
Cechy publikacji
Original article
Inne
System-identifier
PBN-R:837217
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