SPATKIN: a simulator for rule-based modeling of biomolecular site dynamics on surfaces
PBN-AR
Instytucja
Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
BIOINFORMATICS (45pkt w roku publikacji)
ISSN
1367-4803
EISSN
Wydawca
DOI
Rok publikacji
2017
Numer zeszytu
22
Strony od-do
3667-3669
Numer tomu
33
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Język
EN
Treść
Rule-based modeling is a powerful approach for studying biomolecular site dynamics. Here, we present SPATKIN, a general-purpose simulator for rule-based modeling in two spatial dimensions. The simulation algorithm is a lattice-based method that tracks Brownian motion of individual molecules and the stochastic firing of rule-defined reaction events. Because rules are used as event generators, the algorithm is network-free, meaning that it does not require to generate the complete reaction network implied by rules prior to simulation. In a simulation, each molecule (or complex of molecules) is taken to occupy a single lattice site that cannot be shared with another molecule (or complex). SPATKIN is capable of simulating a wide array of membrane-associated processes, including adsorption, desorption and crowding. Models are specified using an extension of the BioNetGen language, which allows to account for spatial features of the simulated process. AVAILABILITY AND IMPLEMENTATION: The C?++?source code for SPATKIN is distributed freely under the terms of the GNU GPLv3 license. The source code can be compiled for execution on popular platforms (Windows, Mac and Linux). An installer for 64-bit Windows and a macOS app are available. The source code and precompiled binaries are available at the SPATKIN Web site (http://pmbm.ippt.pan.pl/software/spatkin).
Cechy publikacji
original-article
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System-identifier
5566
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