Synthesis and evaluation of cytotoxic activity of conjugated linoleic acid derivatives (esters, alcohols, and their acetates) toward cancer cell lines
PBN-AR
Instytucja
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY (30pkt w roku publikacji)
ISSN
1438-7697
EISSN
1438-9312
Wydawca
WILEY-BLACKWELL
DOI
URL
Rok publikacji
2017
Numer zeszytu
10
Strony od-do
1600470
Numer tomu
119
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 5)
Pozostali autorzy
+ 3
Słowa kluczowe
angielski
Anticancer effects
Conjugated linoleic acid
Conjugated linoleyl acetate
Conjugated linoleic alcohol
Cytotoxic activity
Streszczenia
Język
angielski
Treść
Conjugated linoleic acid (CLA) is natural unsaturated fatty acid known for the wide biological propertiestherefore is available in functional food and cosmetics and as a dietary supplements. In this study a seriesof simple derivatives of cis-9,trans-11 and trans-10,cis -12 CLA and a mixture of those isomers have beenproposed as alternative for free CLA preparations. Obtained in high yields (>72%) ethyl esters, alcohols,and their acetates have been subjected to in vitro cytotoxic assay against human tumor cells (humanpromyelocytic leukemia, breast cancer, and colon cancer) and compered with stearic and linoleicderivatives. Studies showed that the growth inhibitory activities depended on the degree of unsaturation.All CLA derivatives except ethyl esters showed similar activities compared to free CLA isomers.Moreover, this study showed that trans-10,cis-12 CLA derivatives have better anticancer propertiesagainst all tested tumor cells than derivatives of cis-9,trans-11 isomer and a mixture of both isomers.Practical applications: This paper make a contribution in the field of study of biological activity ofCLA derivatives and completes deficiencies in spectroscopic data of known isomers of ethyl esters ofCLA isomers, conjugated octadecadienoic alcohols and their acetates. Obtained compounds can be usedas a components of cosmetics and food supplements.
Cechy publikacji
artykuł oryginalny
Inne
System-identifier
PX-59e5f03cd5deb524de423202
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