Design of boron nitride/gelatin electrospun nanofibers for bone tissue engineering
PBN-AR
Instytucja
Centrum Nanobiomedyczne (Uniwersytet im. Adama Mickiewicza w Poznaniu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
ACS Applied Materials & Interfaces (40pkt w roku publikacji)
ISSN
1944-8244
EISSN
Wydawca
AMER CHEMICAL SOC
DOI
URL
Rok publikacji
2017
Numer zeszytu
39
Strony od-do
33695-33706
Numer tomu
9
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
Biocompatibility
Biomechanics
Biomolecules
Bone
Boron nitride
Cell culture
Crosslinking
Elastic moduli
Electrospinning
Fillers
Fourier transform infrared spectroscopy
Gene expression
Mechanical properties
Medical applications
Nanosheets
Nitrides
Phosphatases
Scanning electron microscopy
Tissue
X ray diffraction
Alkaline phosphatase activity
Biodegradable biopolymers
Biomedical applications
Bionanocomposites
Bone tissue engineering
Electrospun nanofibers
Gelatin
Glutaraldehyde cross-linking
Tissue engineering
Streszczenia
Język
en
Treść
Gelatin is a biodegradable biopolymer obtained by collagen denaturation, which shows poor mechanical properties. Hence, improving its mechanical properties is very essential toward the fabrication of efficient nontoxic material for biomedical applications. For this aim, various methods are employed using external fillers such as ceramics or bioglass. In this report, we introduce boron nitride (BN)- reinforced gelatin as a new class of two-dimensional biocompatible nanomaterials. The effect of the nanofiller on the mechanical behavior is analyzed. BN is efficiently exfoliated using the biopolymer gelatin as shown through Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD). The exfoliated BN reinforces gelatin electrospun fibers, which results in an increase in the Young's modulus. The Electrospun Mats (ESM) are stable after the glutaraldehyde cross-linking, and the fibrous morphology is preserved. The crosslinked gelatin/BN ESM is highly bioactive in forming bonelike hydroxyapatite as shown by scanning electron microscopy. Due to their enhanced mineralization ability, the cross-linked ESM have been tested on human bone cells (HOS osteosarcoma cell line). The cell attachment, proliferation, and biocompatibility results show that the ESM are nontoxic and biodegradable. The analysis of osteoblast gene expression and the measurement of alkaline phosphatase activity confirm that these materials are suitable for bone tissue engineering. © 2017 American Chemical Society.
Cechy publikacji
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:873940
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