Can storage time improve the physical stability of amorphous pharmaceuticals with tautomerization ability exposed to compression? The case of a chloramphenicol drug
PBN-AR
Instytucja
Wydział Matematyki, Fizyki i Chemii (Uniwersytet Śląski w Katowicach)
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
MOLECULAR PHARMACEUTICS (45pkt w roku publikacji)
ISSN
1543-8384
EISSN
Wydawca
AMER CHEMICAL SOC
DOI
URL
Rok publikacji
2018
Numer zeszytu
5
Strony od-do
1928-1940
Numer tomu
15
Liczba arkuszy
0,60
Słowa kluczowe
angielski
amorphous pharmaceuticals;
BDS; chemical equilibration;
chloramphenicol;
compression of amorphous APIs;
dielectric spectroscopy;
impact of elevated pressure on physical stability;
improvement stability;
molecular dynamics;
physical stability
Streszczenia
Język
angielski
Treść
In this article we thoroughly investigated the physical stability of the amorphous form of a chloramphenicol drug. The tendency toward recrystallization of this drug has been examined (i) at nonisothermal conditions by means of a DSC technique; (ii) at isothermal conditions and temperature close to Troom by means of dielectric spectroscopy; (iii) at isothermal conditions and elevated temperatures of T = 323 K and 338 K by dielectric spectroscopy; and (iv) at conditions imitating the manufacturing procedure (i.e., elevated temperature and compression procedure). Our investigations have shown that amorphous chloramphenicol, stored at both standard storage and elevated temperature conditions, does not reveal a tendency toward recrystallization. However, compression significantly changes this behavior and destabilizes the examined compound. We found that due to chemical equilibration of the sample, the elongation of the storage time before compression might improve the physical stability of the examined pharmaceutical exposed to compression 34-times.
Cechy publikacji
original-article
Inne
System-identifier
3342900144925
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