How do yeast and other fungi recognize and respond to genome perturbations?
PBN-AR
Instytucja
Instytut Biochemii i Biofizyki Polskiej Akademii Nauk
Książka
Tytuł książki
Stress Response Mechanisms in Fungi. Theoretical and Practical Aspects.
Data publikacji
2018
ISBN
978-3-030-00682-2
Wydawca
Springer
Publikacja
Główny język publikacji
EN
Tytuł rozdziału
How do yeast and other fungi recognize and respond to genome perturbations?
Rok publikacji
2018
Strony (od-do)
87-130
Numer rozdziału
3
Identyfikator DOI
Liczba arkuszy
10,29
Hasło encyklopedyczne
Słowa kluczowe
EN
Yeast;
fungi;
recognize genome perturbations
Streszczenia
Język
EN
Treść
The integrity of a cellular genome may be endangered in many ways. However, cells are not powerless and indifferent to their future fate; they are prepared to solve various problems concerning their genome to enable their survival. Maintaining a stable genome is a complicated task, even without any external problems such as genotoxic agents, irradiation, or any other harmful treatment to which cells are exposed in their environment. Inaccuracies in replication alone may lead to changes in DNA sequence, i.e., to mutations. When cells are exposed to stressful conditions that cause DNA lesions, the frequency of mutations increases. Moreover, unrepaired DNA damage may lead to the replication fork block that delays the replication round until the damage is repaired. However, if for some reason the DNA damage in the replication fork remains unrepaired, it may lead to DNA breakage causing DNA rearrangements or to fork collapse followed by cell death. Consequently, DNA damage is dangerous for replicating cells. What happens when DNA damage appears after a replication round has been successfully finished? Various DNA lesions may disturb the transcription efficiency of the affected genes. DNA strand breaks may generate problems during chromosome segregation because such lesions may lead to an unequal DNA distribution to daughter cells. How Do Yeast and Other Fungi Recognize and Respond to Genome Perturbations?: Theoretical and Practical Aspects | Request PDF. Available from: https://www.researchgate.net/publication/328311326_How_Do_Yeast_and_Other_Fungi_Recognize_and_Respond_to_Genome_Perturbations_Theoretical_and_Practical_Aspects [accessed Oct 31 2018].
Inne
System-identifier
PX-5bd9ab25d5dee9cd5d88557e
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