Layered gelatin/PLLA scaffolds fabricated by electrospinning and 3D printing- for nasal cartilages and subchondral bone reconstruction
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Materials & Design (35pkt w roku publikacji)
ISSN
0261-3069
EISSN
1873-4197
Wydawca
Elsevier Science Ltd.
DOI
Rok publikacji
2018
Numer zeszytu
Strony od-do
297--306
Numer tomu
155
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
0.71
Autorzy
(liczba autorów: 7)
Pozostali autorzy
+ 6
Autorzy przekładu
(liczba autorów przekładu: 0)
Słowa kluczowe
EN
3D printing
electrospinning
gelatin
PLLA
hydroxyapatite and collagen based drug
Streszczenia
Język
EN
Treść
In the present work the advantages of two kinds of different, well known and applicable, biomaterials (PLLA and gelatin) and two kinds of scaffold fabrication techniques (3D printing - FDM and electrospinning) were combined in order to create a novel multifunctional layered scaffold for nasal cartilages and subchondral bone reconstruction. The pore size of scaffolds produced by 3D printing technology was designed to solve the problem that otolaryngologists currently have with fixing the nasal cartilage implant with needle and threads. The effect of the solution concentration for the electrospinning process on the microstructure and mechanical properties of gelatin nanofibers produced as well as the influence of drug concentration on the mechanical properties of membranes were investigated. The commercially available FDM – 3D printing system was used. 3D scaffolds varying in structure and geometry were designed and printed. The influence of the internal architecture of 3D printed scaffolds on their mechanical properties was tested. Hybrid layered scaffolds consisting of a top gelatin nanofibrous layer and a bottom 3D printed porous PLLA material were developed. The mineralization ability of a scaffold was determined in simulated body fluid. The cytotoxicity, proliferation and morphology of Murine fibroblasts L929 cultured on obtained biomaterials were evaluated.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:114582
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