Animal models of smoke inhalation injury and related acute and chronic lung diseases
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Advanced Drug Delivery Reviews (50pkt w roku publikacji)
ISSN
0169-409X
EISSN
1872-8294
Wydawca
Elsevier
DOI
Rok publikacji
2018
Numer zeszytu
Strony od-do
107--134
Numer tomu
123
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
2
Autorzy
Pozostali autorzy
+ 5
Słowa kluczowe
EN
large animals
small animals
lung injury models
smoke inhalation
Streszczenia
Język
EN
Treść
Smoke inhalation injury leads to various acute and chronic lung diseases and thus is the dominant cause of firerelated fatalities. In a search for an effective treatment and validation of therapies different classes of animal models have been developed, which include both small and large animals. These models have advanced our understanding of the mechanism of smoke inhalation injury, enabling a better understanding of pathogenesis and pathophysiology and development of new therapies. However, none of the animal models fully mirrors human lungs and their pathologies. All animal models have their limitations in replicating complex clinical conditions associated with smoke inhalation injury in humans. Therefore, for a correct interpretation of the results and to avoid bias, a precise understanding of similarities and differences of lungs between different animal species and humans is critical. We have reviewed and presented comprehensive comparison of different animal models and their clinical relevance. We presented an overview of methods utilized to induce smoke inhalation injuries, airway micro-/macrostructure, advantages and disadvantages of the most commonly used small and large animal models.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:113091
CrossrefMetadata from Crossref logo
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