Bioconjugation of Ionophore Antibiotics: A Way to Obtain Hybrids with Potent Biological Activity
PBN-AR
Instytucja
Wydział Chemii (Uniwersytet im. Adama Mickiewicza w Poznaniu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
MINI-REVIEWS IN ORGANIC CHEMISTRY (20pkt w roku publikacji)
ISSN
1570-193X
EISSN
Wydawca
BENTHAM SCIENCE PUBL LTD
DOI
URL
Rok publikacji
2017
Numer zeszytu
4
Strony od-do
258-271
Numer tomu
14
Liczba arkuszy
Autorzy
(liczba autorów: 2)
Pozostali autorzy
+ 1
Słowa kluczowe
en
Ionophore antibiotics;
monensin;
salinomycin;
bioconjugation;
hybrid compounds;
anticancer activity;
antibacterial activity
Streszczenia
Język
en
Treść
Polyether antibiotics (ionophores) represent a large group of lipophilic compounds which are able to form complexes with the metal cations and transport them across the lipid membranes. This process disturbs the intercellular Na+/K+ concentration gradient and intracellular pH and leads to the mitochondrial injuries, cell swelling, vacuolization and finally to apoptosis process. For this reason, ionophores are commonly used in veterinary medicine as the non-hormonal growth-promoting and coccidio-static agents. In this group, particularly interesting are monensin and salinomycin because of their proved anti-tumour activity, including efficiency against multidrug-resistant cancer cells and cancer stem cells. Prompted by the idea that cancer cells may be individually effectively killed by these compounds, a very interesting direction of research is bioconjugation process of ionophores. This review is focused on the possible role of hybrids of ionophore antibiotics with other biologically active substances in anti-cancer and anti-bacterial treatment and gives an overview of their properties.
Cechy publikacji
Review
Inne
System-identifier
PX-5b28d893d5de79ce9d021646
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