Severe infections caused by multidrug-resistant non-fermentative bacilli in southern Poland
PBN-AR
Instytucja
Wydział Nauk o Zdrowiu (Wyższa Szkoła Medyczna w Sosnowcu)
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Advances in Clinical and Experimental Medicine
ISSN
1230-025X
EISSN
Wydawca
WROCLAW MEDICAL UNIV
DOI
URL
Rok publikacji
2018
Numer zeszytu
3
Strony od-do
1-7
Numer tomu
27
Identyfikator DOI
Liczba arkuszy
0,8
Słowa kluczowe
angielski
pneumonia
multidrug resistance
non-fermentative bacilli
bloodstream infections
Open access
Tryb otwartego dostępu
Otwarte czasopismo
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Wersja opublikowana
Licencja otwartego dostępu
Creative Commons — Uznanie autorstwa-Niekomercyjne
Czas opublikowania w otwartym dostępie
Po publikacji
Ilość miesięcy od publikacji
2
Data udostępnienia w sposób otwarty
Streszczenia
Język
angielski
Treść
Abstract Background. The impact of multidrug-resistant organisms (MDROs), including non-fermentative bacilli (NFBs), isrising and underestimated, especially inintensive care units (ICUs). Thegrowing prevalence ofmultidrug resistance (MDR) and extensive drug resistance (XDR) is challenging for clinicians, as the treatment options are limited. Objectives. Thepurpose ofthis study was toanalyze the extent of the epidemiological problem ofmultidrugresistant, extensively drug-resistant and pandrug-resistant (PDR) non-fermentative bacilli isolated from pneumonia and bloodstream infections (BSIs) inpatients hospitalized insouthern Poland. Material and methods. This study included 253 NFBs belonging to Acinetobacter sp. (ACI), Pseudomonas sp. (PAR), and Stenotrophomonas sp. (STM). Themicroorganisms were identified, and susceptibility testing was performed using asemi-automatic system. Thedifferent patterns of resistance were defined as MDR, XDR, or PDR strains. Epidemiological typing of A. baumannii from ICUs was performed by repetitive polymerase chain reaction (rep-PCR). Results. More than half of the strains (57.7%) were isolated within ICUs. ACI-strains came significantly more often from ICU wards. Thehighest prevalence of ACI and PAR was found inpneumonia, whereas STM dominated inBSIs. ACIs were more frequently resistant than other pathogens toall studied antibiotics except colistin (n = 76; 58.9%), and they belonged to the XDR category. DiversiLab demonstrated the presence of2 dominant clones inthe ACI group, both classified as European Clone 2 (EUII). Conclusions. Our results indicate serious potential therapeutic problems related tohigh antibiotic resistance of ACI isolates. Thestratification ofdrug resistance (MDR/XDR/PDR) may become animportant tool for the assessment of public health epidemiology and microbiological hazards at the local, national, and international level. Itallows clear presentation of the issues concerning the epidemiology ofhighly resistant bacilli, and the exchange of information between medical staff and local representatives of public health for the implementation ofeffective measures toreduce drug resistance.
Cechy publikacji
Oryginalny artykuł naukowy
Inne
System-identifier
PX-5ab8ea49d5de54f3101d9148
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