Design of Therapeutic Self-Assembled Monolayers of Thiolated Abiraterone
PBN-AR
Instytucja
Wydział Chemii (Uniwersytet Warszawski)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Nanomaterials (35pkt w roku publikacji)
ISSN
2079-4991
EISSN
Wydawca
MDPI - Open Access Publishing
DOI
Rok publikacji
2018
Numer zeszytu
12
Strony od-do
1018
Numer tomu
8
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
self-assembled monolayer
thiolated abiraterone
thioglycolic acid (GA)
electrochemistry
gold electrode; capacity
oxygen reduction
Streszczenia
Język
en
Treść
The aim of our work was to synthetize of a new analogue of abiraterone—thiolated abiraterone (HS-AB) and design a gold surface monolayer, bearing in mind recent advances in tuning monolayer structures and using them as efficient drug delivery systems. Therapeutic self-assembled monolayers (TSAMs) were prepared by chemically attaching HS-AB to gold surfaces. Their properties were studied by voltammetry and atomic force microscopy (AFM). A gold electrode with immobilized thioglycolic acid (HS-GA) was used for comparison. The surface concentration of HS-AB on the gold surface was 0.572 nmol/cm2, determined from the area of the voltammetric reduction peaks (desorption process). The area per one molecule estimated from the voltammetry experiments was 0.291 nmol/cm2. The capacity of thus prepared electrode was also tested. The calculated capacity for the HS-AB modified electrode is 2.90 F/cm2. The obtained value indicates that the monolayer on the gold electrode is quite well ordered and well-packed. AFM images show the formation of gold nanoparticles as a result of immersing the HS-AB modified gold electrode in an aqueous solution containing 1 mM HAuCl43H2O. These structures arise as a result of the interaction between the HS-AB compound adsorbed on the electrode and the AuCl4 􀀀 ions. The voltammetric experiments also confirm the formation of gold structures with specific catalytic properties in the process of oxygen reduction.
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Original article presents the results of original research or experiment
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Inne
System-identifier
PX-5c71272dd5ded152d1f3b9bf
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