Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries
PBN-AR
Instytucja
Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Nature Microbiology
ISSN
2058-5276
EISSN
Wydawca
Nature Research
Rok publikacji
2018
Numer zeszytu
Strony od-do
898-908
Numer tomu
3
Identyfikator DOI
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Autorzy
Pozostali autorzy
+ 37
Słowa kluczowe
en
faecal resistome
pigs
broilers
European
Streszczenia
Język
en
Treść
Antimicrobial resistance (AMR) in bacteria and associated human morbidity and mortality is increasing. The use of antimicrobials in livestock selects for AMR that can subsequently be transferred to humans. This flow of AMR between reservoirs demands surveillance in livestock and in humans. We quantified and characterized the acquired resistance gene pools (resistomes) of 181 pig and 178 poultry farms from nine European countries, sequencing more than 5,000 Gb of DNA using shotgun metagenomics. We quantified acquired AMR using the ResFinder database and a second database constructed for this study, consisting of AMR genes identified through screening environmental DNA. The pig and poultry resistomes were very different in abundance and composition. There was a significant country effect on the resistomes, more so in pigs than in poultry. We found higher AMR loads in pigs, whereas poultry resistomes were more diverse. We detected several recently described, critical AMR genes, including mcr-1 and optrA, the abundance of which differed both between host species and between countries. We found that the total acquired AMR level was associated with the overall country-specific antimicrobial usage in livestock and that countries with comparable usage patterns had similar resistomes. However, functionally determined AMR genes were not associated with total drug use.
Cechy publikacji
praca doświadczalna
Inne
System-identifier
2026
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