3D tissue modelling of skeletal muscle tissue
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej (Politechnika Warszawska)
Książka
Tytuł książki
Biofabrication and 3D Tissue Modeling
Data publikacji
2019
ISBN
978-1-78801-198-3
Wydawca
Royal Society of Chemistry
Publikacja
Główny język publikacji
en
Tytuł rozdziału
3D tissue modelling of skeletal muscle tissue
Rok publikacji
2019
Strony (od-do)
184-216
Numer rozdziału
Identyfikator DOI
Liczba arkuszy
1.6
Hasło encyklopedyczne
Autorzy
Pozostali autorzy
+ 5
Streszczenia
Język
en
Treść
Skeletal muscle tissue exhibits endogenous ability to regenerate. However, the self-repair mechanism is restricted only to small damages. The increasing number of extensive injuries of skeletal muscles due to various accidents, more active life-style or cancer resection, combined with the shortcomings of the conventional treatment procedures, creates demand for new, more advanced solutions. Muscle tissue engineering (TE) appears as a promising strategy for fabrication of tissue substitutes from biomaterials, cells and bioactive factors, alone or combined. In this chapter, we present current state of the art of regeneration and engineering of skeletal muscle tissue. The chapter begins with a brief introduction to structure and functions of skeletal muscle tissue, followed by discussion of cells with potential for repair of muscle injuries and dysfunctions. Next, we provide an overview of natural and synthetic biomaterials used in skeletal muscle TE, as well as description of techniques used to process the biomaterials into scaffolds. We also highlight the importance of mechanical and electrical stimulation during in vitro culture and their effect on cell differentiation and maturation. Last but not least, the latest results of in vivo studies are reported. The chapter is concluded with a short summary and outlook on future developments.
Inne
System-identifier
WUT333c04bb953148ca80791bb09fea9c27
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