Drug-drug interactions between antiepileptics and cannabinoids
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Expert Opinion on Drug Metabolism & Toxicology
ISSN
1742-5255
EISSN
Wydawca
INFORMA HEALTHCARE
DOI
URL
Rok publikacji
2019
Numer zeszytu
5
Strony od-do
407-415
Numer tomu
15
Identyfikator DOI
Liczba arkuszy
1.38
Słowa kluczowe
en
Antiepileptic drugs
cannabidiol
cannabinoid agonists
epilepsy
seizures
Streszczenia
Język
en
Treść
Introduction: About 40\% of patients with epilepsy are associated with drug-resistant seizures, therefore there has been a continuous search for novel treatment approaches. In experimental studies, natural and synthetic cannabimimetic compounds alone or combined with antiepileptic drugs (AEDs) have been extensively studied and cannabidiol, a naturally occurring compound, has been involved in a number of clinical trials. Areas covered: The authors have performed a literature search (PubMed database up to December 2018) for studies evaluating interactions between AEDs and cannabinoid receptor ligands in experimental models of seizures. Clinical data relate to the add-on treatment with cannabidiol. Expert opinion: WIN55,212-2 mesylate (WIN, a non-selective agonist of CB1 and CB2 receptors) significantly potentiated the anticonvulsant activity of various AEDs in mice. Profound neurotoxic effects accompanied combinations of WIN with conventional AEDs. Among conventional and newer AEDs, ACEA (a selective CB1 receptor agonist) enhanced the protective action of phenobarbital and levetiracetam without accompanying adverse effects or pharmacokinetic interactions. Cannabidiol proved effective in clinical trials, reducing seizure frequency and the most frequently observed adverse effects were diarrhea, somnolence, and poor appetite. The retention rate was within 14-24\% (12-14 weeks - 1 year) but it reached the level of 35\% after 2 years.
Cechy publikacji
discipline:Biochemia – dziedzina nauk biologicznych
discipline:Biologia medyczna
discipline:Medycyna
discipline:Nauki farmaceutyczne
discipline:Biochemistry – field of biological sciences
discipline:Medical biology
discipline:Medicine
discipline:Pharmacy
Review article
Review article is a summarization of the current state of the research on a particular subject.
Artykuł przeglądowy
Artykuł przeglądowy stanowi podsumowanie aktualnego stanu badań w danym obszarze tematycznym.
Inne
System-identifier
PBN-R:913802
CrossrefMetadata from Crossref logo
Cytowania
Liczba prac cytujących tę pracę
Brak danych
Referencje
Liczba prac cytowanych przez tę pracę
Brak danych