Dietary chicory inulin-rich meal exerts greater healing effects than fructooligosaccharide preparation in rats with trinitrobenzenesulfonic acid-induced necrotic colitis
PBN-AR
Instytucja
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Polish Journal of Food and Nutrition Sciences
ISSN
1230-0322
EISSN
2083-6007
Wydawca
DOI
URL
Rok publikacji
2019
Numer zeszytu
2
Strony od-do
147-155
Numer tomu
69
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
TNBS-induced colitis
microbiota activity
short-chain fatty acids
chicory roots
Wistar rat
Streszczenia
Język
en
Treść
The aim of the study was to compare the effects of chicory root inulin-rich meal (containing polyphenolic fraction as well) and pure fructooligosaccharides (FOS) on necrotic colitis induced with trinitrobenzenesulfonic acid (TNBS) in Wistar rats. Both chicory preparations significantly reduced the pH of colonic digesta and favourably lowered the caecal activity of bacterial β-glucuronidase as well as the caecal concentration of putrefactive short-chain fatty acids in comparison to the control TNBS rats. Both chicory preparations enhanced the production of total short-chain fatty acid (SCFA pool) and concentration of anti-inflammatory propionic acid in the caecal digesta. Nevertheless, only dietary chicory meal favourably increased the total SCFA concentration and thus decreased the pH of caecal digesta. Increased caecal SCFA production may explain observed greater reduction in mucosal necrosis and increase in glandular mucosal regeneration in rats fed a diet with chicory root meal. Both chicory preparations beneficially regulated physiological parameters in the lower part of the rat intestinal tract after TNBS-induced colitis, however the dietary treatment with chicory meal showed stronger reduction of mucosal disturbances caused by colitis. Those beneficial effects might be related to higher polymerization of inulin vs. FOS and presence of biologically active compounds in the meal, i.e., phenolic compounds, which have strong impact on intestinal microbial activity and thus indirectly alleviated mucosal disturbances caused by colitis.
Inne
System-identifier
252-003905
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