Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility?
PBN-AR
Instytucja
Wojskowy Instytut Higieny i Epidemiologii im. gen. Karola Kaczkowskiego
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Journal of Sports Science and Medicine
ISSN
1303-2968
EISSN
Wydawca
JOURNAL SPORTS SCIENCE & MEDICINE
DOI
URL
Rok publikacji
2019
Numer zeszytu
1
Strony od-do
137-145
Numer tomu
18
Identyfikator DOI
Liczba arkuszy
Autorzy
Pozostali autorzy
+ 14
Słowa kluczowe
angielski
Soft tissue injuries, ACL rupture, IL1B, IL6, IL6R
Streszczenia
Język
angielski
Treść
Cytokines, such as interleukins, are crucial in regulating critical cell signaling pathways as well as being major contributors to inflammatory response and are upregulated during ligament and tendon injuries. The genes encoding key interleukins, such as IL1B and IL6 as well as interleukin receptor IL6R, were chosen as candidate genes for association with soft tissue injuries. The aim of the case-control study was to verify the hypothesis that sequence variants rs1143627, rs16944, rs1800795, rs2228145 in the IL1B, IL6 and IL6R genes are associated with ACL rupture susceptibility in a Polish population. Among four analyzed SNPs, the rs1800795 IL6 gene polymorphism was found to be the only one significantly associated with ACL rupture (p = 0.010, p = 0.022, p = 0.004 for codominant, recessive and overdominant models, respectively; odds ratio = 1.74, 95% CI 1.08-2.81, sex adjusted p = 0.032 for recessive model). With reference to the other analyzed polymorphisms, we failed to show significant differences in the genotype and allele frequencies for IL6R rs2228145as well as IL1B rs16944 and rs1143627 (analyzed alone or in haplotype combination) between the ACL rupture group and the healthy control group among Polish participants. Due to the nature of case-control studies, the results of this study need to be confirmed in independent studies with larger sample sizes. Key points A number of studies have suggested associations between ACL rupture and polymorphisms in the structural genes, possibly proposing that genetic predisposition is a factor of importance in ACL rupture. It is highly unlikely that only the IL1B, IL6 and IL6R genes are exclusively associated with ACL rupture susceptibility. This study supports the hypothesis that not a single, but rather multiple genetic variants are associated with risk of ACL injuries.
Inne
System-identifier
PX-5cf8c5b5d5de57f062a1fb67