The diagnostic potential of glutathione S-transferase (GST) polymorphisms in patients with colorectal cancer
PBN-AR
Instytucja
Instytut Włókien Naturalnych i Roślin Zielarskich
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Advances in Clinical and Experimental Medicine (15pkt w roku publikacji)
ISSN
1899-5276
EISSN
2451-2680
Wydawca
Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
DOI
Rok publikacji
2018
Numer zeszytu
11
Strony od-do
1561-1566
Numer tomu
27
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
1.00
Słowa kluczowe
en
colon cancer
gene polymorphism
GSTM1
GSTT1
multiplex polymerase chain reaction
Streszczenia
Język
en
Treść
Background. Colorectal cancer (CRC) is one of the most common cancers in the world. Despite improvements in screening for early diagnosis, CRC is one of the leading causes of cancer deaths. Objectives. The aim of the study was to determine a potential association between the frequency of GSTM1 and GSTT1 null genotypes and the risk of CRC in the Polish population. Moreover, we analyzed the clinical parameters with the glutathione S-transferase (GST) gene polymorphisms in patients with CRC. Material and methods. The study was conducted on 512 Caucasians, including 279 patients (105 women and 174 men) with CRC. DNA from peripheral blood was extracted and the multiplex polymerase chain reaction (PCR) technique was used for glutathione S-transferase theta (GSTT1) and mu (GSTM1) gene deletion genotyping. Results. We found no statistically significant differences in the frequency of the GST gene polymorphisms in patients with CRC and controls. The prevalence of the GSTM1*0 variant in the test subjects was higher than in controls (45.9% vs 42.9%; p > 0.05). The frequency of the GSTT1*0 variant was also higher in patients with CRC compared to the control population (21.1% vs 18.9%; p > 0.05). In addition, the effect of the GSTM1 and GSTT1 polymorphisms on the incidence of CRC was also analyzed. There was a slight, but not statistically significant, increase of the risk of colon cancer for the GSTM1*0 and GSTT1*0 variants. Moreover, we examined the GST genotype due to the cancer TNM classification and the location of the primary tumor. Statistically significant differences in the distribution of the GSTT1*0 and GSTT1*1 genotypes in both the stage and the location of the primary tumor were observed. Conclusions. It is suggested that the GSTT1 polymorphism may have an impact on the severity of the tumor and its location.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
902966
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