Beneficial effect of ovocystatin on the cognitive decline in APP/PS1 transgenic mice
PBN-AR
Instytucja
Wydział Biotechnologii i Nauk o Żywności (Uniwersytet Przyrodniczy we Wrocławiu)
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Advances in Medical Sciences
ISSN
1896-1126
EISSN
1898-4002
Wydawca
Elsevier Sp. z o.o.
DOI
URL
Rok publikacji
2019
Numer zeszytu
Strony od-do
65-71
Numer tomu
64
Identyfikator DOI
Liczba arkuszy
0.5
Autorzy
(liczba autorów: 9)
Pozostali autorzy
+ 7
Autorzy przekładu
(liczba autorów przekładu: 0)
Słowa kluczowe
angielski
Alzheimer's disease
Cognitive decline
Cystatin C
Mice
Ovocystatin
Streszczenia
Język
angielski
Treść
Purpose: Cystatin C plays an important role in the course of neurodegenerative diseases and has a beneficial effect through inhibiting cysteine proteases and amyloid-β aggregation. It also induces proliferation and autophagy. Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice. Materials/methods: The study was conducted on transgenic B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax mice. Ovocystatin was administered to four-month-old transgenic (AD) and wild type (NCAR) mice in drinking water for 24 weeks (at a dose of 40 and 4 μg/ mouse). The locomotor activity and cognitive functions were determined using an actimeter and the Morris water maze test, respectively. Results: The results of the study indicate that ovocystatin has a beneficial effect on the cognitive functions in APP/PS1 transgenic mice. The strongest effects of ovocystatin were found in the group of AD mice, where ovocystatin was administered in drinking water at a dose of 40 μg/mouse (p < 0.05). Mice from the AD group swam statistically significantly further in the target zone during the trial in the Morris water maze compared to the AD (vehiculum) group (p < 0.05). Conclusions: The obtained results encourage further research into the protective effect, which may be used as an adjuvant in the treatment of deteriorating cognitive functions.
Inne
System-identifier
UPWr6424e23411424bfb993f1f333debcf2b
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