Characterization of Linear and Nonlinear Optical Properties of Phosophorylated CREB Protein for Application in Biosensing
PBN-AR
Instytucja
Wydział Elektryczny (Politechnika Częstochowska)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Materials Chemistry and Physics
ISSN
0254-0584
EISSN
Wydawca
Elsevier
URL
Rok publikacji
2019
Numer zeszytu
Strony od-do
141-144
Numer tomu
Vol.233
Liczba arkuszy
Autorzy
(liczba autorów: 5)
Pozostali autorzy
+ 3
Słowa kluczowe
en
nonlinear optics
biomaterials
optical materials and properties
phosphorylated protein
Preeclampsia
Streszczenia
Język
en
Treść
The design of novel detection method of phosphorylated CREB is crucial for creation of the detection method with higher sensitivity, selectivity, short response time and low price. In this work novel optical and nonlinear optical detection methods for phosphorylated CREB are proposed and confirmed. We have applied two approaches to solve this problem. The first one - completely novel OCSM with higher coordination selectivity is designed. The second one - different absorption spectral peaks are used to measure the phosphorylated level of CREB. The proposed approach demonstrates a great advantage in sensitivity, selectivity and response time with respect to the existed. The principal innovation of this approach is based on the supra-molecular interactions among the designed organic conjugated small molecule (OCSM), Zr4+ ion and phosphorylated CREB. Due to the strong and special interaction between Zr4+ ion and phosphate groups, such method shows an enhancement of the sensitivity . As a nonlinear optical method is proposed to use the second harmonic generation (SHG).
Cechy publikacji
original-article
Inne
System-identifier
61138
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