Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder : a systematic review
PBN-AR
Instytucja
Wydział Filozoficzny (Uniwersytet Jagielloński w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Molecular Neurobiology (40pkt w roku publikacji)
ISSN
0893-7648
EISSN
1559-1182
Wydawca
DOI
URL
Rok publikacji
2018
Numer zeszytu
6
Strony od-do
5075 -5100
Numer tomu
55
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 7)
Pozostali autorzy
+ 6
Słowa kluczowe
EN
psychosis
gene polymorphism
bipolarity
gene × environment interaction
Open access
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Streszczenia
Język
EN
Treść
Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with high heritability rates. The contribution of genetic factors to the etiology of these disorders is increasingly being recognized as the action of multiple risk variants with small effect sizes, which might explain only a minor part of susceptibility. On the other site, numerous environmental factors have been found to play an important role in their causality. Therefore, in recent years, several studies focused on gene × environment interactions that are believed to bridge the gap between genetic underpinnings and environmental insults. In this article, we performed a systematic review of studies investigating gene × environment interactions in BD and schizophrenia spectrum phenotypes. In the majority of studies from this field, interacting effects of variation in genes encoding catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF), and FK506-binding protein 5 (FKBP5) have been explored. Almost consistently, these studies revealed that polymorphisms in COMT, BDNF, and FKBP5 genes might interact with early life stress and cannabis abuse or dependence, influencing various outcomes of schizophrenia spectrum disorders and BD. Other interactions still require further replication in larger clinical and non-clinical samples. In addition, future studies should address the direction of causality and potential mechanisms of the relationship between gene × environment interactions and various categories of outcomes in schizophrenia and BD.
Cechy publikacji
original-article
peer-reviewed
Inne
System-identifier
70421