3D Printing of Thermoresponsive Polyisocyanide (PIC) Hydrogels as Bioink and Fugitive Material for Tissue Engineering
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej (Politechnika Warszawska)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Polymers (40pkt w roku publikacji)
ISSN
2073-4360
EISSN
Wydawca
DOI
URL
Rok publikacji
2018
Numer zeszytu
5
Strony od-do
555-555
Numer tomu
10
Identyfikator DOI
Liczba arkuszy
0.3
Autorzy
Pozostali autorzy
+ 5
Słowa kluczowe
pl
polimery termoreaktywne
Rusztowania 3D hydrożelowe
Bioprinting 3D
hydrożele poliizocyj ankowe (PIC)
podwójny system hydrożelowy
en
thermoresponsive polymers
3D hydrogel scaffolds
3D bioprinting
polyisocyanide (PIC) hydrogels
dual hydrogel system
Streszczenia
Język
en
Treść
Despite the rapid and great developments in the field of 3D hydrogel printing, a major ongoing challenge is represented by the development of new processable materials that can be effectively used for bioink formulation. In this work, we present an approach to 3D deposit, a new class of fully-synthetic, biocompatible PolyIsoCyanide (PIC) hydrogels that exhibit a reverse gelation temperature close to physiological conditions (37 °C). Being fully-synthetic, PIC hydrogels are particularly attractive for tissue engineering, as their properties—such as hydrogel stiffness, polymer solubility, and gelation kinetics—can be precisely tailored according to process requirements. Here, for the first time, we demonstrate the feasibility of both 3D printing PIC hydrogels and of creating dual PIC-Gelatin MethAcrylate (GelMA) hydrogel systems. Furthermore, we propose the use of PIC as fugitive hydrogel to template structures within GelMA hydrogels. The presented approach represents a robust and valid alternative to other commercial thermosensitive systems—such as those based on Pluronic F127—for the fabrication of 3D hydrogels through additive manufacturing technologies to be used as advanced platforms in tissue engineering.
Inne
System-identifier
WUTf109f169b4c448cbab96ff163f98fab5
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