Comparative studies of biological activity of cadmium-based quantum dots with different surface modifications
PBN-AR
Instytucja
Wydział Chemiczny (Politechnika Warszawska)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Applied Nanoscience
ISSN
2190-5509
EISSN
Wydawca
DOI
URL
Rok publikacji
2018
Numer zeszytu
3
Strony od-do
309-321
Numer tomu
8
Identyfikator DOI
Liczba arkuszy
0.6
Słowa kluczowe
en
Quantum dots
Nanoparticles
Toxicity
Apoptosis
Necrosis
Reactive oxygen species
Streszczenia
Język
en
Treść
This paper presents a modification of the surface of CdS/ZnS and CdSe x S1−x/ZnS quantum dots (QDs) with 3-mercaptopropionic and 6-mercaptohexanoic acid. The obtained QDs were characterized using TEM, DLS, UV–Vis, and fluorescence spectroscopy. Flow cytometry was applied to evaluate the cytotoxicity of QDs and examine the type of death caused by the tested nanoparticles. In addition, the generation of reactive oxygen species after incubation of the tested cells with CdSe x S1−x/ZnS–MPA and CdSe x S1−x/ZnS–MHA QDs was evaluated. The study was conducted on three cell lines: adherent (A549 and MRC-5) and suspension ones (K562). The conducted research demonstrated that the tested nanoparticles exhibit concentration-dependent toxicity. It was observed that the surface modification influences the toxicity level of the examined QDs, and modification of their surface with the use of the ligand of longer carbon chain (MHA) reduces the toxicity in comparison with QDs–MPA. It was also found that all tested QDs caused the death of cells in the course of necrosis. Based on obtained results, it was concluded that the cytotoxicity of QDs is to a large extent related to reactive oxygen species (ROS) generation.
Inne
System-identifier
WUT6f82cea8138040158998c91f6ee2f22d
CrossrefMetadata from Crossref logo
Cytowania
Liczba prac cytujących tę pracę
Brak danych
Referencje
Liczba prac cytowanych przez tę pracę
Brak danych