The influence of selected ω-mercaptocarboxylate ligands on physicochemical properties and biological activity of Cd-free, zinc‑copper‑indium sulfide colloidal nanocrystals
PBN-AR
Instytucja
Wydział Chemiczny (Politechnika Warszawska)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Materials Science & Engineering C - Materials for Biological Applications
ISSN
0928-4931
EISSN
Wydawca
Elsevier BV
DOI
Rok publikacji
2019
Numer zeszytu
Strony od-do
583-592
Numer tomu
97
Identyfikator DOI
Liczba arkuszy
0.5
Słowa kluczowe
en
Quantum dots
Cytotoxicity
Surface modification
ω-Mercaptocarboxylate ligan
Streszczenia
Język
en
Treść
In this work core/shell cadmium-free zinc‑copper‑indium sulfide ZnCuInS/ZnS quantum dots (QDs) originally stabilized with hydrophilic alkanethiol were modified with 3-mercaptopropionic acid (MPA) or 6-mercaptohexanoic acid (MHA) via two-step ligand exchange method. The obtained QDs were further characterized by TEM, UV Vis, and fluorescence spectroscopy. Both types of QDs were non-toxic in a wide range of concentrations. To our knowledge, our studies are the first attempt to determine the type of cell death and reactive oxygen species production level as a result of incubation of cell cultures with ZnCuInS/ZnS QDs. Furthermore, the accumulation of QDs in vitro was examined on three human cell lines by fluorescence intensity measurements and visualized by confocal microscopy. The modification of QDs with a ligand characterized by slightly longer aliphatic chain (MHA), instead of typically used MPA turns out to be beneficial both from the point of colloidal stability, preservation of optical properties during ligand exchange as well as reflects in a higher cellular uptake. This contribution can be beneficial from the point of view of the selection of the optimal ligands and concentrations in the case of ZnCuInS/ZnS core-shell QDs for biological applications.
Inne
System-identifier
WUTb945cd407dcd49e9921ff14bbc336e78
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