Anticancer agents found in environment affect Daphnia at population, individual and molecular levels.
PBN-AR
Instytucja
Instytut Biochemii i Biofizyki Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
AQUATIC TOXICOLOGY
ISSN
0166-445X
EISSN
1879-1514
Wydawca
ELSEVIER SCIENCE BV
DOI
URL
Rok publikacji
2019
Numer zeszytu
brak
Strony od-do
105288
Numer tomu
215
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
EN
Pharmaceuticals;
Alkylating agents;
Cyclophosphamide;
Cisplatin;
Life history;
Proteome
Streszczenia
Język
EN
Treść
Pharmaceuticals are used in medical treatment on a large scale and as a waste contaminate freshwater ecosystems. Growing amount of so-called civilization diseases, such as different type of cancer, significantly contribute to this form of pollution. The aim of the present study was to determine how the exposure to chemotherapeutics: cyclophosphamide (CP) and cisplatin (CDDP), at detected in environment concentrations, influence proteome profile, life history and population parameters of naturally setting surface waters Daphnia pulex and Daphnia pulicaria. The parameters important for crustaceans, survivorship and population growth rate, were importantly decreased by CDDP treatment but not influenced by CP. On the contrary, the individual growth rate was affected only by CP and exclusively in the case of D. pulicaria. In both clones treated with CP or CDDP, decreased number of eggs was observed. Interestingly, Daphnia males were less sensitive to tested chemotherapeutic than females. Proteome profile revealed that tested anticancer pharmaceuticals modified expression of some proteins involved in Daphnia metabolism. Moreover, males exposed to CDDP showed increased level of enzymes participating in DNA repair. Summing up, the contaminating environment chemotherapeutics reduced fitness of naturally occurring Daphnia species. In consequence this may affect functioning of the aquatic food webs.
Inne
System-identifier
PX-5d7f8428d5de0e3fc4c7b2f2
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