Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications
PBN-AR
Instytucja
Wydział Fizyki (Uniwersytet im. Adama Mickiewicza w Poznaniu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Oxidative Medicine and Cellular Longevity (30pkt w roku publikacji)
ISSN
1942-0900
EISSN
1942-0994
Wydawca
LANDES BIOSCIENCE
DOI
URL
Rok publikacji
2017
Numer zeszytu
Strony od-do
1-15
Numer tomu
3
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
fluoroquinolones
adverse reaction
Fluoroquinolone Associated Disability
mitochondrial potential
apoptosis
vitamin E
n-acetylcysteine
Fenton Reaction
gene expression
oxidative stress
electron transport chain
Krebs Cycle
Reactive Oxygen Species
Permeability Transition Pore
hydrogen peroxide
superoxide
hydroxyl radical
fluoroquinolone toxicity
Hypoxia Inducible Factor
Streszczenia
Język
en
Treść
Long-term fluoroquinolone-associated disability (FQAD) after fluoroquinolone (FQ) antibiotic therapy appears in recent years as a significant medical and social problem, because patients suffer for many years after prescribed antimicrobial FQ treatment from tiredness, concentration problems, neuropathies, tendinopathies, and other symptoms. The knowledge about the molecular activity of FQs in the cells remains unclear in many details. The effective treatment of this chronic state remains difficult and not effective. The current paper reviews the pathobiochemical properties of FQs, hints the directions for further research, and reviews the research concerning the proposed treatment of patients. Based on the analysis of literature, the main directions of possible effective treatment of FQAD are proposed: (a) reduction of the oxidative stress, (b) restoring reduced mitochondrion potential ΔΨm, (c) supplementation of uni- and bivalent cations that are chelated by FQs and probably ineffectively transported to the cell (caution must be paid to Fe and Cu because they may generate Fenton reaction), (d) stimulating the mitochondrial proliferation, (e) removing FQs permanently accumulated in the cells (if this phenomenon takes place), and (f) regulating the disturbed gene expression and enzyme activity.
Cechy publikacji
discipline:Biochemia – dziedzina nauk biologicznych
discipline:Biologia medyczna
discipline:Medycyna
discipline:Biochemistry – field of biological sciences
discipline:Medical biology
discipline:Medicine
Review article
Review article is a summarization of the current state of the research on a particular subject.
Artykuł przeglądowy
Artykuł przeglądowy stanowi podsumowanie aktualnego stanu badań w danym obszarze tematycznym.
Inne
System-identifier
PBN-R:857480
CrossrefMetadata from Crossref logo
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