p0722: Intrathecal infusion of autologic adipose derived regenerative cells (ADRC)  in an autoimmune determined refractory epilepsy
PBN-AR
Instytucja
Instytut Matki i Dziecka
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Epilepsia (40pkt w roku publikacji)
ISSN
0013-9580
EISSN
1528-1167
Wydawca
WILEY-BLACKWELL
DOI
URL
Rok publikacji
2017
Numer zeszytu
S5 Special Issue:32nd International Epilepsy Congress
Strony od-do
S132-S132
Numer tomu
58
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Konferencja
Indeksowana w Scopus
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Nazwa konferencji (skrócona)
32nd International Epilepsy Congress
Nazwa konferencji
32nd International Epilepsy Congress, Barcelona, Spain, 2nd - 6th September 2017
Początek konferencji
2017-09-02
Koniec konferencji
2017-09-06
Lokalizacja konferencji
Barcelona
Kraj konferencji
ES
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Streszczenia
Język
angielski
Treść
Purpose: Taking into account that ADRC isolated from lipid tissue are supposed to have immunomodulatory, neuroprotective, trophic and antiapoptotic qualities an evaluation of safety and efficacy of ADRC in autoimmune determined refractory epilepsies was undertaken. Method: After bioethic commission agreement, 6 patients with mean age of 10 years, and with proven or probable autoimmune refractory epilepsy (2 with Rasmussen encephalitis, 2 with neuronal autoantibodies, 2 with possible FIRES) were included into the project. A procedure of intrathecal infusion of ADRC acquired through liposuction followed by isolation by Cytori machine were performed. Procedure was repeated 3 times every 3 months in each patient. Neurological status, cognitive function and antiepileptic effect were supervised during 12 months of follow-up. Results: Immediately after procedure all patients were in good condition. In individual cases transient mildly elevated body temperature, pain in regions of liposuction or slight increasing of number of seizures during 24 hours were noted. During next months, cognitive functioning and manual performance improved in all patients. One patient has been seizure free up today. In other patients frequency of seizures was different: from reduction of their number to lack of improvement. Conclusion: Autologous ADRC therapy may constitute a new option for some patients with autoimmune determined refractory epilepsy. Based on our trial and other clinical data the autologic ADRC therapy appears to be safe. Antiepileptic efficacy proved to be various, however cognitive abilities improved in all children.
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streszczenie z konferencji
Inne
System-identifier
PX-5d4952d2d5de6b69dfa54458
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