Antioxidant defence in the brain of 1-d-old chickens exposed in ovo to acrylamide
PBN-AR
Instytucja
Wydział Geograficzno-Biologiczny (Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
BRITISH POULTRY SCIENCE (30pkt w roku publikacji)
ISSN
0007-1668
EISSN
1466-1799
Wydawca
TAYLOR & FRANCIS LTD
DOI
Rok publikacji
2018
Numer zeszytu
2
Strony od-do
198-204
Numer tomu
59
Identyfikator DOI
Liczba arkuszy
Autorzy
Pozostali autorzy
+ 1
Słowa kluczowe
en
antioxidative enzymes
brain
chickens
embryos
reduced glutathione
acrylamide
Streszczenia
Język
en
Treść
1. Acrylamide (ACR) is a potent neurotoxicant, although information on its toxic influence on developing neural system is still limited. We examined the effect of in-ovo-injected ACR on the antioxidant system activity in the brain of new hatched chicks. This model eliminated the mother’s contribution to embryonic development. It was also recognized as an adequate model for animal embryonic development. 2. ACR was injected on day 4 of embryogenesis– in doses of 1.25 and 2.50 mg per egg (n=40 eggs per each group/120 eggs). The doses corresponded well with ACR doses used in other animal studies and their concentrations in certain animal feeds. 3. Mortality and incidences of malformations were not found to increase significantly. Significant depletion of GSH was detected in the cerebellum, cerebrum and medulla oblongata of specimens exposed to the highest doses of ACR. Enzymatic activity was affected by the highest ACR doses. GPx activity increased significantly in the cerebrum, medulla oblongata and the hypothalamus. SOD activity increased significantly in hypothalamus and decreased in cerebellum and cerebrum. A significant depletion of catalase activity was detected in cerebellum. In the hypothalamus, the increased SOD/GPx and SOD/CAT ratios suggest the risk of H2O2. 4. We concluded that ACR significantly influences the antioxidative defense in the chicken brain at the tested doses.
Inne
System-identifier
20198
CrossrefMetadata from Crossref logo
Cytowania
Liczba prac cytujących tę pracę
Brak danych
Referencje
Liczba prac cytowanych przez tę pracę
Brak danych