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Advanced age of renal transplant recipients correlates with increased plasma concentrations of interleukin-6, chemokine ligand 2 (CCL2), and matrix metalloproteinase 2, and urine concentrations of CCL2 and tissue inhibitor of metalloproteinase 1

Artykuł
Czasopismo : Transplantation Proceedings   Tom: 46, Zeszyt: 8, Strony: 2640-2643
O[ktawia] Mazanowska [1] , M[arcelina] Żabińska [1] , K[atarzyna] Kościelska-Kasprzak [1] , D[orota] Kamińska [1] , M[irosław] Banasik [1] , M[agdalena] Krajewska [1] , K[atarzyna] Madziarska [1] , S[ławomir] C. Zmonarski [1] , P[aweł] Chudoba [2] , P. Biecek [3] , M[aria] Boratyńska [1] , M[arian] Klinger [1]
2014 angielski
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  • Oryginalny artykuł naukowy
  • Zrecenzowana naukowo
Abstrakty ( angielski )
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Abstract Background Advanced age of renal transplant recipients (RTRs) has a negative impact on kidney allograft survival through impaired extracellular matrix degradation by the matrix metalloproteinases/tissue inhibitors of metalloproteinases (MMPs/TIMPs) system. Moreover, older RTRs are at risk of smoldering inflammation, known as inflammaging. Aim The aim of the study was to assess the impact of a RTR's age on plasma and urine concentrations of interleukin 6 (IL-6), chemokine ligand 2 (CCL2), and the MMPs/TIMPs system. Material and Methods One hundred fifty adult RTRs (8.7% ≥ 65 years) and 37 adult healthy volunteers (10.8% ≥ 65 years) were enrolled in the study. The studied factors (IL-6, CCL2, MMP-2, MMP-9, TIMP-1 and TIMP-2) were quantified in plasma and urine with enzyme-linked immunosorbent assay. The Mann-Whitney U test and Spearman's (rs) rank correlation were applied, and differences with a P < .05 were considered statistically significant. Results There was a weak but significant positive correlation between increasing RTR's age and plasma IL-6 (rs = 0.18, P = .028), CCL2 (rs = 0.27, P = .001), and MMP-2 (rs = 0.20, P = .017), as well as urine CCL2 (rs = 0.16, P = 0.050) and TIMP-1 (rs = 0.20, P = .014) concentrations. Conclusions Advancing age of RTRs correlates with increasing plasma IL-6 and CCL2 concentrations, reflecting smoldering inflammation (known as inflammaging) and alterations in MMPs/TIMPs profiles, especially with increased plasma MMP-2 and urine TIMP-1 concentrations.
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