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Dane publikacji

DETERMINATION OF ENDOGENOUS STEROIDS IN HUMAN AND RAT URINES AND INFLUENCE OF ETHANOL INGESTION ON STEROID PROFILE

Rozdział
Anna Jarek [1] , Marzena Wójtowicz [1] , Katarzyna Chajewska [1] , Anna Małkowska [2] , Wanda Dyr [3] , Dorota Kwiatkowska [1]
2015 angielski
Liczba arkuszy: 0,1
Link do publicznie dostępnego pełnego tekstu
Cechy publikacji
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  • Abstrakt
  • Zrecenzowana naukowo
  • Konferencyjna
Dyscypliny naukowe
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Chemia
Słowa kluczowe
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Dane konferencji
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  1. EUROANALYSIS XVIII, 18th edition of EuroAnalysis the European Conference on Analytical Chemistry
  2. 2015-09-06 - 2015-09-10
  3. Bordeaux, Francja
Abstrakty ( angielski )
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Ethanol is a substance widely available on the market and its consumption is strongly rooted in the culture. Nevertheless, the effects of alcohol ingestion have already been the subject of numerous researches covering all branches of medicine, its influence on human metabolism in context of anti-doping analysis is still open to discuss. The aim of the project was to evaluate the influence of alcohol consumption on the concentrations of selected endogenous anabolic-androgenic steroids, namely: testosterone, pitestosterone, dehydroepiandrosterone, androsterone, etiocholanolone, 5-α- ndrostandiol and 5-β-androstandiol. The group of 39 healthy volunteers, both men and female, and the population of 16 rats from Warsaw Hight Prefering lines were involved in this study. The human and rat urine samples were analyzed by gas chromatography-mass spectrometry and gas chromatography-triple quadruple mass spectrometry, respectively. Both quantitative methods of steroid profile have been validated. Each of volunteers ingested 2 mg of alcohol per kilogram of body mass in less than half an hour and the urine samples were collected for 6 days. In order to observe the correlation between the concentrations of steroids and remaining alcohol, the content of ethyl glucuronide was also investigated. The rat population had an unlimited access to the 10% ethanol and water, and the urine samples were collected every 12 h for 6 days. The obtained results have shown that the single ethanol ingestion can disturb the concentrations of selected steroids enough to result in atypical findings in anti-doping results.
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