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GSTP1 c.313A>G polymorphism in Russian and Polish athletes

Artykuł
Czasopismo : PHYSIOLOGICAL GENOMICS   Tom: 49, Strony: 127-131
Aleksandra Zarębska [1] , Zbigniew Jastrzębski, [2] , Ildus I. Ahmetov [3] , Piotr Żmijewski [4] , Paweł Cięszczyk [5] , Agata Leońska-Duniec [6] , Marek Sawczuk [5] , Katarzyna Leźnicka [6] , Grzegorz Trybek [7] , Ekaterina A. Semenowa [8] , Agnieszka Maciejewska-Skrendo [5]
  • [1]
    Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Gdansk, Poland
  • [2]
    Gdansk University of Physical Education and Sport
  • [3]
    Volga Region State Academy of Physical Culture, Sport and Tourism
  • [4]
  • [5]
    University of Szczecin
  • [6]
    Centre for Human Functional and Structural Research, Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland
  • [7]
    Pomeranian Medical University
  • [8]
    Kazan Federal University, Kazan, Russia
2017 angielski
Identyfikatory
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Cechy publikacji
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  • Oryginalny artykuł naukowy
  • Zrecenzowana naukowo
Dyscypliny naukowe
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Nauki o kulturze fizycznej , Nauki o zdrowiu
Słowa kluczowe
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Abstrakty ( angielski )
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The GSTP1 gene encodes glutathione S-transferase P1 which is a member of glutathione S-transferases (GSTs) that are a family of enzymes playing an important role in detoxification and in the antioxidant defense system. There were some the evidence indicating that GSTP1 c.313A>G polymorphism may be beneficial for exercise performance. Therefore, we have decided to verify the association between the frequency of GSTP1 c.313A>G variants, physical performance and athlete's status in two cohorts: in a group of Russian athletes (n=507) and in an independent population of Polish athletes (n=510) in a replication study. The initial association study conducted with the Russian athletes revealed that the frequency of the minor G allele was significantly higher in all athletes than in controls, that was confirmed in the replication study of Polish athletes. In the combined cohort, the differences between athletes (n=1017) and controls (n=1246) were even more pronounced (32.7 vs 25.0%, P < 0.0001). Our findings emphasize that the G allele of the GSTP1 gene c.313A>G SNP is associated with improved endurance performance. These observations could support the hypothesis that the GSTP1 G allele may improve exercise performance by better elimination of exercise-induced ROS.
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