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Short-term D-aspartic Acid Supplementation Does Not Affect Serum Biomarkers Associated With the Hypothalamic-Pituitary-Gonadal Axis in Male Climbers

Czasopismo : International Journal of Sport Nutrition and Exercise Metabolism   Tom: brak, Zeszyt: brak, Strony: 1-17
2018 angielski
Liczba arkuszy: 1
Cechy publikacji
  • Oryginalny artykuł naukowy
  • Zrecenzowana naukowo
Dyscypliny naukowe
Nauki o kulturze fizycznej , Nauki o zdrowiu
Słowa kluczowe
Abstrakty ( angielski )
D-aspartic acid (DAA) is promoted as a testosterone (T) enhancing supplement via mechanisms involving the hypothalamic-pituitary-gonadal (HPG) axis. Here we investigated the short-term effects of DAA on serum biomarkers of the HPG-axis in male climbers. Using a single-blinded, placebo-controlled design, 16 climbers were randomly assigned to either a DAA (3 g·d−1) or placebo (3 g·d−1) supplement for two weeks. The reverse treatment commenced after a two-week washout, with all conditions administered in a balanced manner. The subjects maintained their normal weekly training across this study. Serum samples taken before and after each treatment were analysed for T, luteinizing hormone (LH), sex hormone binding globulin (SHBG), cortisol (C), and free T was calculated (cFT). The DAA supplement did not significantly affect serum T, cFT and LH levels. Only a main effect of time on SHBG (6.8% increase) and C (13.6% decrease) emerged (p<0.03). Significant negative associations were identified between pre-test values and changes (%) in T, cFT, LH and C levels with DAA and/or placebo, but these relationships did not differ between treatments (p>0.46). Additional measures of physical function and serum haematology also failed to respond to DAA. In summary, a daily dose of DAA during a short training period did not influence T and selected indicators of the HPG-axis in male climbers. Other parameters linked to athletic performance and health status were also unaffected. Our findings support evidence showing that DAA (including DAA-blended supplements) at either recommended or higher dosages does not afford any ergogenic benefits for athletic males.
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